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WHEP-TRS protein domain
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WHEP-TRS protein domain : ウィキペディア英語版
WHEP-TRS protein domain

In molecular biology, the protein domain WHEP-TRS refers to helix-turn-helix domains. They are found in variable numbers in a particularly common protein, named, glutamyl-prolyl tRNA synthetase(EPRS). This protein domain has an important function in protein–protein interactions between synthetases. WHEP domains exhibit high-affinity interactions with tRNA, indicating a putative evolutionary relationship to facilitate tRNA binding to fused synthetases, thereby enhancing catalytic efficiency.
==Protein interactions==
EPRS is a component of the interferon-gamma-activated inhibitor of translation (GAIT) complex, which interacts with stem-loop elements (GAIT elements) in mRNAs encoding proinflammatory proteins, for example, vascular endothelial growth factor-A (VEGFA). WHEP domains interact with the GAIT element in the 3′UTR of target mRNAs and with the regulatory protein NS1-associated protein-1 (NSAP1).〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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